Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates
IntroductionDecreasing rates of blood donation and close margins between blood supply and demand pose challenges in healthcare.Genetically engineered pig red blood cells (pRBCs) have been explored as alternatives to human RBCs for transfusion, and triple-gene knockout (TKO) modification improves the compatibility of pRBCs with human blood in vitro.